Tigecycline (Tygacil)

Class of antibiotic > glyclycline (although it is in its own class, it is similar in structure to tetracyclines. Technically it is a derivative of minocycline) – Inhibits protein synthesis of bacterial cell walls (prokaryotic translation) by binding to the 30s subunits of mRNA.  Good activity against susceptible gram-negative, gram-positive, and anaerobes including MRSA. Dose: 50mg IV twice per day after a 100mg loading dose.

Administration: This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.