Ceftriaxone (Rocephin)

Class of Antibiotic > cephalosporininhibits the mucopeptide synthesis in bacterial cell walls, Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ceftriaxone results from the inhibition of cell wall synthesis and is mediated through Ceftriaxone binding to penicillin binding proteins (PBPs). Ceftriaxone is stable against breakdown by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Dose: 1-2 grams IV once per day, diluted in 50-100ml of Normal Saline.  Once per day dosing is common but other schedules are used (twice per day, twice per day four days per week, etc.)

Methods of administration include Elastomeric pumps (“homeballs”) and gravity bags. IV push is sometimes used but not recommended.  Storage: 14 Days refrigerated, 45 Days frozen.