Text Box: Typically we provide Glutathione in a syringe ready for infusion. Some pharmacies manufacture the product and freeze dry it. That requires you to dilute the product first to get it into solution and then draw it out of the vial and put it in a syringe, then do the infusion. While this method does have an advantage when shipping (can be shipped without ice) it has the disadvantage of possible contamination while reconstituting the product. Available Products Glutathione syringe 2 GM in 20 ML solution ready for infusion Glutathione syringe 1 GM in 10 ml solution ready for infusion Glutathione syringe 2.4 GM in 24 ml solution ready for infusion Glutathione 4 GM in 40 ml Glutathione syringe 100mg/ml in 3 ml for oral inhalation. 500mg in 1cc of topical cream Glutathione 200mg/ml—all sizes Below is an except from an email Randy Breton, Pharmacist at Infuserve sent to a customer answering a question about Oral Glutathione vs. Injectable: According to the manufacturers website Acetyl-Glutathione is an oral supplement that comes as a 100mg Capsule that is taken 2-3 times per day. I have found some information relative to the Acetyl Glutathione but it is a little different than the article provided.  In the article the author states “Acetyl –Glutathione is a compound that actually occurs normally in a human body”  This is not what I found during my research.  Below is an excerpt from US patent 5464825 for the manufacture of Acetyl- Glutathione (N-Acetyl Glutathione).  As you can see it is a manufactured product, in addition I have included a copy of glutathione metabolism.  Nowhere in the cascade of metabolism is Acetyl Glutathione mentioned.  Reduced Glutathione is mentioned, however, and this makes the most sense relative to what we currently know about Glutathione (GSH) All items introduced into the human body are acted upon by enzymes – it is the way proteins and other chemicals are processed in our liver and bloodstream, without this constant breakdown of material - toxic substances would build up and we would die.  Glutathione is not an essential nutrient> the body can produce Glutathione from other raw materials (amino acids – L-cysteine, L-glutamic acid, and glycine).  Glutathione normally exists in reduced (GSH) and oxidized (GSSG) states.  In its reduced state (GSH) Glutathione is able to donate a electron to unstable molecules (Free Radicals – unstable oxygen species) by giving up this electron Glutathione itself becomes reactive but is quickly reacts with another form of glutathione to produce Glutathione disulfide (GSSG) -  in an interesting turn of events GSH can be regenerated from GSSG by the enzyme glutathione reductase  (as you can see the “peptidases” referred to by the author of the article, are not always the bad guys).  In Cells and in Tissue – 90% of the total glutathione pool is in the reduced form (GSH).  GSH is used in both conjugation and reduction reactions and the non-enzymatic conjugation of NAPQI (the toxic metabolite produced by an overdose of acetaminophen).  Oral Glutathione is problematic:  oral doses are poorly absorbed.  A study was performed by Witschi and associates that concluded that it was not possible to significantly increase circulating blood levels of glutathione even after a 3gram dose.  ^ Witschi A, Reddy S, Stofer B, Lauterburg BH (1992). "The systemic availability of oral glutathione". Eur J Clin Pharmacol. 43 (6): 667–9 Acetylation of chemicals is common (Aspirin for example)  but is normally done to increase the penetration of the chemical across the blood-brain barrier.  Perhaps this is the origin of the authors claim that Acetyl-Glutathione “is very easily assimilated intracellularly”  It still has to be broken down by enzymes to GSH (deacetylation) in order to have an effect.  One of the other items I am unsure of is-  what has been done to overcome the absorption problem – is there another compound in the Acetyl Glutathione that increases oral absorption?  The patent for N-Acetyl Glutathione does not mention any advantage relative to this.  The only studies I could find that backed up the claim of increased cellular penetration were mice studies (liver and kidney). On the Doctor’s website you provided it states: “the most reliable way is to directly infuse GSH by the intravenous route.  It can done easily and safely in a physician's office.  The usual dosage is 500-2000 mg. two to three times a week.  The down side of this method is the fact that most doctors (even LLMDs) don't do the IV infusions and the high cost (ranges from $50 to $150 per treatment).”   We do not charge nearly that much per treatment, even for the 2 gram dose! And it can be done very safely at home.  Our product is tested for potency and sterility and by the doctor’s own admission is the most reliable way of GSH supplementation. 

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Glutathione (GSH)